General description
A cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC50 = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC50 = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC50 = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.
Packaging
5 mg in Glass bottle
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
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